电话：18992080443

电子邮箱：xyyuan@xzmu.edu.cn

毕业于西北大学中药药物化学专业，博士研究生，讲师，硕士研究生导师，现任西藏民族大学医学院药理学教研室教师，藏药检测技术教育部工程研究中心秘书，西藏藏医药研究中心藏药活性成分及药理机制研究联合实验室成员。在J Chromatogr A、Int J Nanomedicine、Anal Che等以第一作者及通讯作者身份发表论文5篇，参与发表论文20余篇，获得专利1项。中国化学会会员，中国药理学会化疗药理专业委员会青年委员。

主要研究方向：

药物成分分析，藏药复杂体系靶向成分筛选及辨识

重要学术研究成果与贡献：

承担科研项目情况：

1、西藏自治区自然科学基金青年项目，XZ202401ZR0117，2024-07至2026-07，7万元，在研，主持；

2、西藏民族大学校内项目-“青年学人培育计划”资助项目，24MDX01，2024-01至2025-12，5万元，在研，主持；

3、西藏自治区自然科学基金重点项目, ZRKX2025000132, 2025-02 至 2028-02, 23万元, 在研, 参与；

4、国家自然科学基金委员会，地区项目，82460334，2025-01至2028-12，32万元，在研，参与；

5、国家自然科学基金委员会，地区项目，82360368，2024-01至2027-12，32万元，在研，参与；

6、国家自然科学基金委员会, 面上项目, 82174088, 2022-01-01至2025-12-31, 55万元, 在研, 参与；

代表性成果：

[1] 袁心怡，李良喜，赵勤等. 卤代烷烃脱卤素酶标签α_1A-肾上腺素受体色谱方法的建立与评价[J]. 色谱. 2024, 42 (10): 935-942.

[2] Xu Ji, Liangxi Li, Kaiyue Zhang, Xinyi Yuan*, Qian Li, Ge Bai. Screening and analysis of the targeted compounds in Choerospondias axillaris extract by receptor chromatographic column with immobilized angiotensin II type 1 receptor. Biomedical Chromatography. 2024, 38: e5931.

[3] Xu Ji, Liangxi Li, Kaiyue Zhang, Xinyi Yuan*, Xiaoying Zhang, Lu Wang, Qin Zhao. Discovering the Bioactive Compounds Binding to α1A-Adrenergic Receptor in Guizhi Fuling Formula and Revealing Their Interactions by Immobilizing the Receptor Through Colicin L7 DNase/Immunity Protein 7 Ultra-Affinity System. Journal of Separation Science. 2024, 47(23):e70053.

[4] X.Y. Yuan, A. Shayiranbieke, R. Xu, et al. Site-selective covalently immobilized alpha 1A adrenergic receptor for thermodynamic and extra-thermodynamic study of four ligands binding to the receptor by chromatographic methods. J Chromatogr A, 2022, 1665: 462827.

[5] X.Y. Yuan, F.H. Fei, H.M. Sun, et al. Tanshinol borneol ester on nanostructured lipid carriers has longer brain and systemic effector retention and better antioxidant activity in vivo. Int J Nanomedicine, 2018, 13: 2265-2274.

[6]J. Gao, X.Y. Yuan, X.X. Zheng, et al. Two-point immobilization of a conformation-specific beta2-adrenoceptor for recognizing the receptor agonists or antagonists inspired by binding-induced DNA assembly. Biomater Sci, 2021, 9(23): 7934-7943.

[7] G.J. Feng, X.Y. Yuan, P. Li, et al. G protein-coupled receptor-in-paper, a versatile chromatographic platform to study receptor-drug interaction. J Chromatogr A, 2021, 1637: 461835.

[8] J. Wang, X. Zhao, X.Y. Yuan, et al. Rapid screening of bioactive compound in Sanzi Yangqin Decoction and investigating of binding mechanism by immobilized beta2-adrenogic receptor chromatography coupled with molecular docking. J Pharm Biomed Anal, 2021, 197: 113957.

[9] X. Zhao, X.Y. Fu, X.Y. Yuan, et al. Development and characterization of a selective chromatographic approach to the rapid discovery of ligands binding to muscarinic-3 acetylcholine receptor. J Chromatogr A, 2021, 1653: 462443.

[10] X.F. Zhao, Y.H. Jin, X.Y. Yuan, et al. Covalent Inhibitor-Based One-Step Method for Endothelin Receptor A Immobilization: from Ligand Recognition to Lead Identification. Anal Chem, 2020, 92(20): 13750-13758.

授权专利情况：

赵新锋, 王静, 李倩, 袁心怡. 中药活性成分靶向筛选一步可逆方法及试剂盒[P]. 中国专利：CN111983215A, 2020年11月.