性别:女
电子邮箱:xyyuan@xzmu.edu.cn
毕业于西北大学中药药物化学专业,博士研究生,讲师,现任西藏民族大学医学院药理学教研室教师,西藏藏医药研究中心藏药活性成分及药理机制研究联合实验室秘书,藏药检测技术教育部工程研究中心成员。在J Chromatogr A、Int J Nanomedicine、Anal Che等以第一作者身份发表论文 2篇,参与发表论文5篇,获得专利1项。中国化学会会员。
主要研究方向:
药物成分分析,藏药复杂体系靶向成分筛选及辨识
重要学术研究成果与贡献:
近五年的代表性成果:
[1] X.Y. Yuan, A. Shayiranbieke, R. Xu, et al. Site-selective covalently immobilized alpha 1A adrenergic receptor for thermodynamic and extra-thermodynamic study of four ligands binding to the receptor by chromatographic methods. J Chromatogr A, 2022, 1665: 462827. JCR Q2. IF=4.759
[2] X.Y. Yuan, F.H. Fei, H.M. Sun, et al. Tanshinol borneol ester on nanostructured lipid carriers has longer brain and systemic effector retention and better antioxidant activity in vivo. Int J Nanomedicine, 2018, 13: 2265-2274. JCR Q2. IF=6.4
[3] J. Gao, X.Y. Yuan, X.X. Zheng, et al. Two-point immobilization of a conformation-specific beta2-adrenoceptor for recognizing the receptor agonists or antagonists inspired by binding-induced DNA assembly. Biomater Sci, 2021, 9(23): 7934-7943. JCR Q2. IF=6.843
[4] G.J. Feng, X.Y. Yuan, P. Li, et al. G protein-coupled receptor-in-paper, a versatile chromatographic platform to study receptor-drug interaction. J Chromatogr A, 2021, 1637: 461835. JCR Q2. IF=4.759
[5] J. Wang, X. Zhao, X.Y. Yuan, et al. Rapid screening of bioactive compound in Sanzi Yangqin Decoction and investigating of binding mechanism by immobilized beta2-adrenogic receptor chromatography coupled with molecular docking. J Pharm Biomed Anal, 2021, 197: 113957. JCR Q3. IF=3.935
[6] X. Zhao, X.Y. Fu, X.Y. Yuan, et al. Development and characterization of a selective chromatographic approach to the rapid discovery of ligands binding to muscarinic-3 acetylcholine receptor. J Chromatogr A, 2021, 1653: 462443. JCR Q2. IF=4.759
[7] X.F. Zhao, Y.H. Jin, X.Y. Yuan, et al. Covalent Inhibitor-Based One-Step Method for Endothelin Receptor A Immobilization: from Ligand Recognition to Lead Identification. Anal Chem, 2020, 92(20): 13750-13758. JCR Q1. IF=6.986
[8] 赵新锋, 王静, 李倩, 袁心怡. 中药活性成分靶向筛选一步可逆方法及试剂盒[P]. 中国专利:CN111983215A, 2020年11月.
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