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袁心怡

发布时间:2023-03-21 信息来源:医学院 浏览次数:1915
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 姓名:袁心怡

性别:
电子邮箱:xyyuan@xzmu.edu.cn

毕业于西北大学中药药物化学专业,博士研究生,讲师,现任西藏民族大学医学院药理学教研室教师,西藏藏医药研究中心藏药活性成分及药理机制研究联合实验室秘书藏药检测技术教育部工程研究中心成员J Chromatogr AInt J NanomedicineAnal Che等以第一作者身份发表论文 2篇,参与发表论文5篇,获得专利1。中国化学会会员。

主要研究方向:

药物成分分析,藏药复杂体系靶向成分筛选及辨识

重要学术研究成果与贡献:

近五年的代表性成果:

[1] X.Y. Yuan, A. Shayiranbieke, R. Xu, et al. Site-selective covalently immobilized alpha 1A adrenergic receptor for thermodynamic and extra-thermodynamic study of four ligands binding to the receptor by chromatographic methods. J Chromatogr A, 2022, 1665: 462827. JCR Q2. IF=4.759

[2] X.Y. Yuan, F.H. Fei, H.M. Sun, et al. Tanshinol borneol ester on nanostructured lipid carriers has longer brain and systemic effector retention and better antioxidant activity in vivo. Int J Nanomedicine, 2018, 13: 2265-2274. JCR Q2. IF=6.4

[3] J. Gao, X.Y. Yuan, X.X. Zheng, et al. Two-point immobilization of a conformation-specific beta2-adrenoceptor for recognizing the receptor agonists or antagonists inspired by binding-induced DNA assembly. Biomater Sci, 2021, 9(23): 7934-7943. JCR Q2. IF=6.843

[4] G.J. Feng, X.Y. Yuan, P. Li, et al. G protein-coupled receptor-in-paper, a versatile chromatographic platform to study receptor-drug interaction. J Chromatogr A, 2021, 1637: 461835. JCR Q2. IF=4.759

[5] J. Wang, X. Zhao, X.Y. Yuan, et al. Rapid screening of bioactive compound in Sanzi Yangqin Decoction and investigating of binding mechanism by immobilized beta2-adrenogic receptor chromatography coupled with molecular docking. J Pharm Biomed Anal, 2021, 197: 113957. JCR Q3. IF=3.935

[6] X. Zhao, X.Y. Fu, X.Y. Yuan, et al. Development and characterization of a selective chromatographic approach to the rapid discovery of ligands binding to muscarinic-3 acetylcholine receptor. J Chromatogr A, 2021, 1653: 462443. JCR Q2. IF=4.759

[7] X.F. Zhao, Y.H. Jin, X.Y. Yuan, et al. Covalent Inhibitor-Based One-Step Method for Endothelin Receptor A Immobilization: from Ligand Recognition to Lead Identification. Anal Chem, 2020, 92(20): 13750-13758. JCR Q1. IF=6.986

[8] 赵新锋, 王静, 李倩, 袁心怡. 中药活性成分靶向筛选一步可逆方法及试剂盒[P]. 中国专利:CN111983215A, 202011.

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